EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog.
Misfolded proteins of the endoplasmic reticulum (ER) are eliminated by the ER-associated degradation (ERAD) in eukaryotes.In S.cerevisiae, ER-resident lectins mediate substrate recognition through bipartite signals consisting of an unfolded local structure and the Wooden Spoon adjacent glycan.Trimming of the glycan is essential for the directional